SUMMARY
  • Escherichia coli is a wide spread bacteria prevalent in most livestock and has been linked to the transfer of antibacterial resistant E.coli to humans (Price et al., 2007).
  • Inclusion of pHorce in feed increases circulating immune defence cells (CD4+), improving the birds’ readiness to mount an immune response and combat undesirable pathogens.
  • pHorce also increases circulating antibody levels (IgY) contributing to the ability of the bird to maintain a protective immune response on an ongoing basis.

 

BACKGROUND
  • Deaths attributed to common infections resistant to antimicrobials will be the biggest killer in both humans and animals worldwide by 2050 (The Review on Antimicrobial Resistance, 2016).
  • pHorce is classified as a bacterial decontaminating agent (including, but not limited to Salmonella) to improve feed hygiene (Feed Additive Register 2017/940).

 

TRIAL DESIGN

A study was conducted in conjunction with São Paulo University, Brazil (2014). 250 Ross 308 broilers were randomly assigned to 1 of 2 treatments with 5 replicates each. Treatments were as follows. Control (basal diets without pHorce) and pHorce (basal diet with 1 kg/t pHorce in starter, 0.7 kg/t in grower and 0.5 kg/t in finisher). Broilers were challenged orally with E. coli (K88 strain) on day 7 of age to induce sub-clinical disease. Blood samples were taken at 21 and 35 days of age.

RESULTS
  • pHorce supports the immune status of birds following coli challenge. Raised antibody levels reflect an immune system that is both more prepared and more active in responding to unwanted bacteria.
  • pHorce also increased the level of CD4+ relative to CD8+ expression; CD4+ are those cells responsible for dealing with initial contact with unwanted organisms.
  • pHorce can be used alongside medication to combat infection quicker and help to reduce the risk of antibacterial resistant bacteria proliferating.