SUMMARY
  • Escherichia coli is a wide spread bacteria prevalent in most livestock and has been linked to the transfer of antibacterial resistant E.coli to humans (Price et al., 2007).
  • Inclusion of pHorce in feed increases circulating immune defence cells (CD4+), improving the birds’ readiness to mount an immune response and combat undesirable pathogens.
  • pHorce also increases circulating antibody levels (IgY) contributing to the ability of the bird to maintain a protective immune response on an ongoing basis.

 

BACKGROUND
  • Deaths attributed to common infections resistant to antimicrobials will be the biggest killer in both humans and animals worldwide by 2050 (The Review on Antimicrobial Resistance, 2016).
  • pHorce is classified as a bacterial decontaminating agent (including, but not limited to Salmonella) to improve feed hygiene (Feed Additive Register 2017/940).

 

TRIAL DESIGN

A study was conducted in conjunction with São Paulo University, Brazil (2014). 250 Ross 308 broilers were randomly assigned to 1 of 2 treatments with 5 replicates each. Treatments were as follows. Control (basal diets without pHorce) and pHorce (basal diet with 1 kg/t pHorce in starter, 0.7 kg/t in grower and 0.5 kg/t in finisher). Broilers were challenged orally with E. coli (K88 strain) on day 7 of age to induce sub-clinical disease. Blood samples were taken at 21 and 35 days of age.

RESULTS
  • pHorce supports the immune status of birds following E. coli challenge. Raised antibody levels reflect an immune system that is both more prepared and more active in responding to unwanted bacteria.
  • pHorce also increased the level of CD4+ relative to CD8+ expression; CD4+ are those cells responsible for dealing with initial contact with unwanted organisms.
  • pHorce can be used alongside medication to combat infection quicker and help to reduce the risk of antibacterial resistant bacteria proliferating.

 

 

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